The yeast Saccharomyces cerevisiae have been a powerful model to study a host of biological phenomena. The system's powerful genetic approaches are now being tapped to study neuronal proteins that interface with basic cellular machinery. In particular, yeast models of protein folding diseases have been developed to investigate mechanisms of cytotoxicity and to screen for nov el therapeutic targets for a host of neurological disorders, including Parkinson’s Disease, Huntington’s Disease, Prion Diseases and Alzheimer’s Disease.